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242 Ambrosi B, Bara R, Travaglini P, et al Studies of the effects of bromocriptine on sexual impotence Clin Endocrinol (Oxf) 1987;7:417 420 243 Sinha YN Structural variants of prolactin: occurrence and physiological signi cance Endocr Rev 1995;16: 354 369 244 Vallette-Kasic S, Morange-Ramos I, Selim A, et al Macroprolactinemia revisited: a study on 106 patients J Clin Endocrinol Metab 2002;87:581 588 245 Gibney J, Smith TP, McKenna TJ The impact on clinical practice of routine screening for macroprolactin J Clin Endocrinol Metab 2005;90:3927 3932 246 Lemaire C, Lemaire A, Dewailly D, Fossati P Hyperprolactinemia with an excess of high molecular weight prolactin in men Int J Impot Res 1994;6(suppl 1):P79 247 Guay AT, Sabharwal P, Varma S, Malarkey WB Delayed diagnosis of psychological erectile dysfunction because of the presence of macroprolactinemia J Clin Endocr Metab 1996;81:2515 2514 248 Tritos NA, Guay AT, Malarkey WB Asymptomatic big hyperprolactinemia in two men with pituitary adenomas Eur J Endocrinol 1998;138:82 85 249 Buvat J, Lemaire A, Buvat-Herbaut M, Marcolin G Dosage de la prolactine chez les impuissants Presse Med 1989;18:1167 250 Schwartz MF, Bauman JE, Masters WH Hyperprolactinemia and sexual disorders in men Biol Psychiat 1982;17:861 876 251 Molitch ME Medication-induced hyperprolactinemia Mayo Clin Proc 2005;82:1050 1057 252 Porst H, Broemel T Hyperprolactinemia in men with sexual dysfunctions Still a diagnostic challenge J Sex Med 2006;3(suppl 1):53 253 Garg RK, Khaishgi A, Dandona P Is management with Sildena l changing clinical practice Lancet 1999;353: 375 376 254 De Rosa M, Zarrilli S, Di Sarno A, et al Hyperprolactinemia in men Endocrine 2003;20:75 82 255 Passos VQ, Souza JJS, Musolino NRC, Bronstein MD Long-term follow-up of prolactinomas: normoprolactinemia after bromocriptine withdrawal J Clin Endocrinol Metab 2002;87:3578 3582 256 Wolfsberger S, Czech T, Vierhapper H, Benavente R, Knosp E Microprolactinomas in males treated by transsphenoidal surgery Acta Neurochir 2003;145: 935 941 257 Oettel M Is there a role for estrogens in the maintenance of men s health Aging Male 2002;5:248 257 258 Smith EP, Boyd J, Frank RG, Takahashi H, Cohen RM, Specker B et al Estrogen resistance caused by a muta-.

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to seek legal counsel in case there s potential for fraud, which we discuss in this chapter Suspicious about a vendor Checking a vendor s credit rating through Equifax (wwwequifaxca) may tip you off to potential dangers of the sale Also make sure that every last bit of information in the offer to purchase is correct down to the vendor s name and company (if included) Inconsistencies can indicate a potential problem

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272 Legrain S, Massien C, Lahlou N, Roger M, Debuire B, Diquet B, Chatellier G, Azizi M, Faucounau V, Porchet H, Forette F, Baulieu E Dehydroepiandrosterone replacement administration: pharmacokinetic and pharmacodynamic studies in healthy elderly subjects J Clin Endocrinol Metab 2000;85:3208 3217 273 Hayashi T, Esaki T, Muto E, Kano H, Asai Y, Thakur N, et al Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide Arterioscler Thromb Vasc Biol 2000;20:782 792 274 Nawata H, Yanase T, Goto K, Okabe T, Ashida K Mechanism of action of anti-aging DHEA-S and the replacement of DHEA-S Mech Ageing Dev 2002;123: 1101 1106 275 Labrie F Intracrinology Mol Cell Endocrinol 1991;78: C113 118 276 Labrie F, Belanger A, Van LT, Labrie C, Simard J, Cusan L DHEA and the intracrine function of androgens and estrogens in peripheral target tissue: its role during aging Steroids 1998;63:322 328 277 Labrie F, Luu-The V, Lin SX, Simard J, Labrie C, El-Alfy M, Pelletier G, Belanger A Intracrinology: role of the family of 17 -hydroxysteroid dehydrogenases in human physiology and disease J Mol Endocrin 2000;25:1 16 278 Liu D, Dillon J Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a speci c plasma membrane receptor coupled to G i2,3 J Biol Chem 2002;277:21379 21388 279 Liu D, Dillon J Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor Steroids 2004;69: 279 289 280 Simoncini T, Mannella P, Fornari L, Varone G, Caruso A, Genazzani A Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms Endocrinology 2003;144:3449 3455 281 Williams M, Ling S, Dawood T, Hashimura K, Dai A, Li H, Liu J, Funder J, Sudhir K, Komesaroff P Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of androgen and estrogen receptors J Clin Endocrinol Metab 2002;87:176 181 282 Iwasaki Y, Asai M, Yoshida M, Nigawara T, Kambayashi M, Nakashima N Dehydroepiandrosteronesulfate inhibits nuclear factor-kB-dependent transcription in hepatocytes, possibly though antioxidant effect J Clin Endocrinol Metab 2004;89:3449 3454.

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Due diligence is part of closing the deal, but the deal itself also requires scrutiny Two particular areas of interest to you are the financial and legal aspects Double-crunch the numbers to make sure they work and fit in with your worst-case scenario for your portfolio Make sure numbers such as the appraised value, potential return, and similar elements mesh with official figures Legal considerations include making sure you can secure clear title to the property, and that no competing claims to it exist Verify that any renovations you have planned are in accordance with municipal bylaws Consult with your advisers to ensure the deal meets with their approval They have the skills to examine the deal in greater depth than you can, and you should involve them as necessary throughout the due diligence process